KMID : 1147220210220020078
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Journal of Biomedical and Translational Research 2021 Volume.22 No. 2 p.78 ~ p.84
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Inhibitory effect of an ethanol extract mixture of Aralia elata leaf, Chaenomeles sinensis fruit and Glycyrrhizae radix on A¥â (25?35)-induced memory impairment
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Seong Yeon-Hee
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Abstract
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The young shoots of Aralia elata, Chaenomeles sinensis fruit and Glycyrrhizae radix are edible and traditionally used as anti-inflammatory and antioxidant agents. The present study was performed to investigate the protective effect of an ethanol extract mixture of these three medicinal plants (ACG) against amyloid ¥â protein (A¥â) (25?35)-induced memory impairment in an ICR mouse model. Memory impairment was induced by intracerebroventricular microinjection of 15 nmol A¥â (25?35) and assessed using the passive avoidance test and the Morris water maze test. The step-through latency in the passive avoidance test was decreased and the latency to reach the hidden platform in the Morris water maze test was increased in mice treated with A¥â (25?35), indicating memory impairment. This memory impairment induced by A¥â (25?35) was significantly prevented by chronic treatment with ACG (10, 25, and 50 mg/kg, p.o., 8 days). In memory impaired mice brain, cholinesterase activity and concentration of thiobarbituric acid reactive substance, a lipid peroxidation marker, were increased and glutathione level was decreased. These biochemical changes in A¥â (25?35)-treated mice were reversed by chronic administration of ACG. The present results suggest that antioxidant and anti-cholinesterase activities of ACG might be responsible for the inhibition of A¥â (25?35)-induced memory impairment and that ACG preparation may have a therapeutic role in preventing the progression of Alzheimer¡¯s disease.
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KEYWORD
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Aralia elata, Chaenomeles sinensis fruit, Glycyrrhizae radix, antidementia, amyloid ¥â protein
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